| Pair Name | Curcumin, Disulfiram | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Disulfiram (PubChem CID: 3117 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Disulfiram | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Oxidative stress | |||
| In Vitro Model | B16-F10 | Mouse melanoma | Mus musculus (Mouse) | CVCL_0159 |
| In Vivo Model | Tumor cells (2×10⁶ cells per 500 μL) were implanted subcutaneously into the left hind groin of mice. The compounds were dissolved in 5% DMSO and provided to the mice intraperitoneally once a day for 15 consecutive days. | |||
| Result | Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress. Biomolecules. 2022 Oct 31;12(11):1600. doi: 10.3390/biom12111600. | Click |
